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% Chapter 18$Practical Applications of Immunology%%D/Vaccine History".Variolation: Inoculation of smallpox into skin (18th century) Vaccination: Inoculation of cowpox into skin Herd immunity results when most of a population is immune to a disease.*2  zOTPrincipal Vaccines Used in the United States to Prevent Bacterial Diseases in Humans UTcDtaP Diphtheria: Purified diphtheria toxoid Pertussis: Acellular fragments of B. pertussis Tetanus: Purified tetanus toxoid Meningococcal meningitis: Purified polysaccharide from N. meningitidis Haemophilus influenzae type b meningitis: Polysaccharides conjugated with protein Pneumococcal conjugate vaccine: S. pneumoniae antigens conjugated with protein~wI "7\ "   ,$;  "{PPPrincipal Vaccines Used in the United States to Prevent Viral Diseases in Humans QPBSmallpox: Live vaccinia virus Poliomyelitis: Inactivated virus Rabies: Inactivated virus Hepatitis A: Inactivated virus Influenza: Inactivated or attenuated virus Measles: Attenuated virus Mumps: Attenuated virus Rubella: Attenuated virus Chickenpox: Attenuated virus Hepatitis B: Antigenic fragments (recombinant vaccine) ,iN APrecipitation reactions involve soluble antigens with antibodies.|Q Agglutination reactions involve particulate antigens with antibodies. Antigens may be: On a cell (direct agglutination) Attached to latex spheres (indirect or passive agglutination)}R SThe antibody titer is the concentration of antibodies against a particular antigen.~S Hemagglutination involves agglutination of RBCs. 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% Chapter 18$Practical Applications of Immunology%%D/Vaccine History".Variolation: Inoculation of smallpox into skin (18th century) Vaccination: Inoculation of cowpox into skin Herd immunity results when most of a population is immune to a disease.*2  zOTPrincipal Vaccines Used in the United States to Prevent Bacterial Diseases in Humans UTcDtaP Diphtheria: Purified diphtheria toxoid Pertussis: Acellular fragments of B. pertussis Tetanus: Purified tetanus toxoid Meningococcal meningitis: Purified polysaccharide from N. meningitidis Haemophilus influenzae type b meningitis: Polysaccharides conjugated with protein Pneumococcal conjugate vaccine: S. pneumoniae antigens conjugated with protein~wI "7\ "   ,$;  "{PPPrincipal Vaccines Used in the United States to Prevent Viral Diseases in Humans QPBSmallpox: Live vaccinia virus Poliomyelitis: Inactivated virus Rabies: Inactivated virus Hepatitis A: Inactivated virus Influenza: Inactivated or attenuated virus Measles: Attenuated virus Mumps: Attenuated virus Rubella: Attenuated virus Chickenpox: Attenuated virus Hepatitis B: Antigenic fragments (recombinant vaccine) ,iN APrecipitation reactions involve soluble antigens with antibodies.|Q Agglutination reactions involve particulate antigens with antibodies. Antigens may be: On a cell (direct agglutination) Attached to latex spheres (indirect or passive agglutination)}R SThe antibody titer is the concentration of antibodies against a particular antigen.~S Hemagglutination involves agglutination of RBCs. 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% Chapter 18$Practical Applications of Immunology%%D/Vaccine History".Variolation: Inoculation of smallpox into skin (18th century) Vaccination: Inoculation of cowpox into skin Herd immunity results when most of a population is immune to a disease.*2  zOTPrincipal Vaccines Used in the United States to Prevent Bacterial Diseases in Humans UTcDtaP Diphtheria: Purified diphtheria toxoid Pertussis: Acellular fragments of B. pertussis Tetanus: Purified tetanus toxoid Meningococcal meningitis: Purified polysaccharide from N. meningitidis Haemophilus influenzae type b meningitis: Polysaccharides conjugated with protein Pneumococcal conjugate vaccine: S. pneumoniae antigens conjugated with protein~wI "7\ "   ,$;  "{PPPrincipal Vaccines Used in the United States to Prevent Viral Diseases in Humans QPBSmallpox: Live vaccinia virus Poliomyelitis: Inactivated virus Rabies: Inactivated virus Hepatitis A: Inactivated virus Influenza: Inactivated or attenuated virus Measles: Attenuated virus Mumps: Attenuated virus Rubella: Attenuated virus Chickenpox: Attenuated virus Hepatitis B: Antigenic fragments (recombinant vaccine) ,iN APrecipitation reactions involve soluble antigens with antibodies.|Q Agglutination reactions involve particulate antigens with antibodies. Antigens may be: On a cell (direct agglutination) Attached to latex spheres (indirect or passive agglutination)}R SThe antibody titer is the concentration of antibodies against a particular antigen.~S Hemagglutination involves agglutination of RBCs. 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Viral hemagglutination inhibition tests for antibodies by the antibodies' ability to prevent viruses from agglutinating RBCs.HaT MNeutralization reactions eliminate the harmful effect of a virus or exotoxin.C G3Complement Fixation UFluorescent-Antibody Techniques  V0Enzyme-Linked Immunosorbent Assay (Direct ELISA) 10,  W3Enzyme-Linked Immunosorbent Assay (Indirect ELISA) 43,  X  Y hDirect tests detect antigens (from patient sample) Indirect tests detect antibodies (in patient's serum)Z -Agglutination: Particulate antigens Hemagglutination: Agglutination of RBCs Precipitation: Soluble antigens Fluorescent-antibody technique: Antibodies linked to fluorescent dye Complement fixation: RBCs are indicator Neutralization: Inactivates toxin or virus ELISA: Peroxidase enzyme is the indicator   :   I      @ (  @ @ s *f",$D , @ <ȖJ"( {ICopyright 2004 Pearson Education, Inc., publishing as Benjamin CummingsJJ  @ 6(J `0 <$D<  T Click to edit Master title style! ! @ 0J ` `<$ <  W#Click to edit Master subtitle style$ $6  @ 6(J"  DPowerPoint Lecture Slide Presentation prepared by Christine L. Case@En  f f: f3 @ 0蚳J"p ` Microbiology8 Z<f<ff<f @ 0ȟJ" r LB.E Pruitt & Jane J. Stein @ <hJ"! EAN INTRODUCTIONff @ <ȜJ" ] FEIGHTH EDITION fB @ 6D"P,$D , @ 6HJ"0 >TORTORA " FUNKE " CASE2  B @ 6D"P,$D ,B @ s *޽h ? 33rۘ S?( xy   ( frame.html(frame.html(frame.html(frame.html/ 0DTimes New RomanJ6KpR6KNJiBJ6KNJiDArialNew RomanJ6KpR6KNJiBJ6KNJi DGenevaew RomanJ6KpR6KNJiBJ6KNJi0DWingdingsRomanJ6KpR6KNJiBJ6KNJi@DTimesngsRomanJ6KpR6KNJiBJ6KNJiPDSymbolgsRomanJ6KpR6KNJiBJ6KNJi ` .  @n?" dd@  @@`` |m                   R$*r3CVcqR$%}R ` o;pTR$ң J ?GR$X^Ɓ UwKYR$T$,y^<ܯw}S8R$=Tnz|_ZR$@rExUoX#) R$x.rѪ:<0NR$+ \N_)4ɻc $ fffffff@f8b} ʚ;2Nʚ;g4ZdZdN6KiJGJJ(J@p p@ <4!d!dN6KpR6KʚN6K@T<4ddddN6KpR6KʚN6K@T<4BdBdN6KpR6KʚN6K@T g4>d>dN6KiJpR6KN6K p@ ppph___PPT2001D<4Xi? % Chapter 18$Practical Applications of Immunology%%D/Vaccine History".Variolation: Inoculation of smallpox into skin (18th century) Vaccination: Inoculation of cowpox into skin Herd immunity results when most of a population is immune to a disease.*2  zOTPrincipal Vaccines Used in the United States to Prevent Bacterial Diseases in Humans UTcDtaP Diphtheria: Purified diphtheria toxoid Pertussis: Acellular fragments of B. pertussis Tetanus: Purified tetanus toxoid Meningococcal meningitis: Purified polysaccharide from N. meningitidis Haemophilus influenzae type b meningitis: Polysaccharides conjugated with protein Pneumococcal conjugate vaccine: S. pneumoniae antigens conjugated with protein~wI "7\ "   ,$;  "{PPPrincipal Vaccines Used in the United States to Prevent Viral Diseases in Humans QPBSmallpox: Live vaccinia virus Poliomyelitis: Inactivated virus Rabies: Inactivated virus Hepatitis A: Inactivated virus Influenza: Inactivated or attenuated virus Measles: Attenuated virus Mumps: Attenuated virus Rubella: Attenuated virus Chickenpox: Attenuated virus Hepatitis B: Antigenic fragments (recombinant vaccine) ,[Precipitation Reactions (Involve soluble antigens with antibodies )|Q Agglutination reactions involve particulate antigens with antibodies. Antigens may be: On a cell (direct agglutination) Attached to latex spheres (indirect or passive agglutination)}R SThe antibody titer is the concentration of antibodies against a particular antigen.~S Hemagglutination involves agglutination of RBCs. Viral hemagglutination inhibition tests for antibodies by the antibodies' ability to prevent viruses from agglutinating RBCs.HaT MNeutralization reactions eliminate the harmful effect of a virus or exotoxin.C G3Complement Fixation UFluorescent-Antibody Techniques  V0Enzyme-Linked Immunosorbent Assay (Direct ELISA) 10,  W3Enzyme-Linked Immunosorbent Assay (Indirect ELISA) 43,  X  Y hDirect tests detect antigens (from patient sample) Indirect tests detect antibodies (in patient's serum)Z -Agglutination: Particulate antigens Hemagglutination: Agglutination of RBCs Precipitation: Soluble antigens Fluorescent-antibody technique: Antibodies linked to fluorescent dye Complement fixation: RBCs are indicator Neutralization: Inactivates toxin or virus ELISA: Peroxidase enzyme is the indicator   :     P|)(  |l | C HRJ` ]   r | S X4Jy    | 086J,$, = Figure 18.3   * | S i A18-03_Precipitin_1.jpg 00030347 Macintosh HD ABA78158:)3 H | 0޽h ? 33r[ k( xy   ( frame.html(frame.html(frame.html(frame.html/ 0DTimes New RomanJ6KpR6KNJiBJ6KNJiDArialNew RomanJ6KpR6KNJiBJ6KNJi DGenevaew RomanJ6KpR6KNJiBJ6KNJi0DWingdingsRomanJ6KpR6KNJiBJ6KNJi@DTimesngsRomanJ6KpR6KNJiBJ6KNJiPDSymbolgsRomanJ6KpR6KNJiBJ6KNJi ` .  @n?" dd@  @@``  n                  R$*r3CVcqR$%}R ` o;pTR$ң J ?GR$X^Ɓ UwKYR$T$,y^<ܯw}S8R$=Tnz|_ZR$@rExUoX#) R$x.rѪ:<0NR$+ \N_)4ɻc $ fffffff@f8b} ʚ;2Nʚ;g4ZdZdN6KiJGJJ(J@p p@ <4!d!dN6KpR6KʚN6K@T<4ddddN6KpR6KʚN6K@T<4BdBdN6KpR6KʚN6K@T g4>d>dN6KiJpR6KN6K p@ ppph___PPT2001D<4Xi? % Chapter 18$Practical Applications of Immunology%%D/Vaccine History".Variolation: Inoculation of smallpox into skin (18th century) Vaccination: Inoculation of cowpox into skin Herd immunity results when most of a population is immune to a disease.*2  zOTPrincipal Vaccines Used in the United States to Prevent Bacterial Diseases in Humans UTcDtaP Diphtheria: Purified diphtheria toxoid Pertussis: Acellular fragments of B. pertussis Tetanus: Purified tetanus toxoid Meningococcal meningitis: Purified polysaccharide from N. meningitidis Haemophilus influenzae type b meningitis: Polysaccharides conjugated with protein Pneumococcal conjugate vaccine: S. pneumoniae antigens conjugated with protein~wI "7\ "   ,$;  "{PPPrincipal Vaccines Used in the United States to Prevent Viral Diseases in Humans QPBSmallpox: Live vaccinia virus Poliomyelitis: Inactivated virus Rabies: Inactivated virus Hepatitis A: Inactivated virus Influenza: Inactivated or attenuated virus Measles: Attenuated virus Mumps: Attenuated virus Rubella: Attenuated virus Chickenpox: Attenuated virus Hepatitis B: Antigenic fragments (recombinant vaccine) ,[Precipitation Reactions (Involve soluble antigens with antibodies )\Agglutination Reactions Involve particulate antigens and antibodies Antigens may be: On a cell (direct agglutination) Attached to latex spheres (indirect or passive agglutination)&#r }R SThe antibody titer is the concentration of antibodies against a particular antigen.~S Hemagglutination involves agglutination of RBCs. Viral hemagglutination inhibition tests for antibodies by the antibodies' ability to prevent viruses from agglutinating RBCs.HaT MNeutralization reactions eliminate the harmful effect of a virus or exotoxin.C G3Complement Fixation UFluorescent-Antibody Techniques  V0Enzyme-Linked Immunosorbent Assay (Direct ELISA) 10,  W3Enzyme-Linked Immunosorbent Assay (Indirect ELISA) 43,  X  Y hDirect tests detect antigens (from patient sample) Indirect tests detect antibodies (in patient's serum)Z -Agglutination: Particulate antigens Hemagglutination: Agglutination of RBCs Precipitation: Soluble antigens Fluorescent-antibody technique: Antibodies linked to fluorescent dye Complement fixation: RBCs are indicator Neutralization: Inactivates toxin or virus ELISA: Peroxidase enzyme is the indicator   :     `5(  r  S LJ` ]   x  c $hSJH   _foodmatefoodmateJJJ   0/J,$, = Figure 18.4   *  S A18-04_AgglutReaction_1.jpg 00030347 Macintosh HD ABA78158:^  H  0޽h ? 33r\  ( xy   ( frame.html(frame.html(frame.html(frame.html/ 0DTimes New RomanJ6KpR6KNJiBJ6KNJiDArialNew RomanJ6KpR6KNJiBJ6KNJi DGenevaew RomanJ6KpR6KNJiBJ6KNJi0DWingdingsRomanJ6KpR6KNJiBJ6KNJi@DTimesngsRomanJ6KpR6KNJiBJ6KNJiPDSymbolgsRomanJ6KpR6KNJiBJ6KNJi ` .  @n?" dd@  @@`` ( o                 R$*r3CVcqR$%}R ` o;pTR$ң J ?GR$X^Ɓ UwKYR$T$,y^<ܯw}S8R$=Tnz|_ZR$@rExUoX#) R$x.rѪ:<0NR$+ \N_)4ɻc $ fffffff@f8b} ʚ;2Nʚ;g4ZdZdN6KiJGJJ(J@p p@ <4!d!dN6KpR6KʚN6K@T<4ddddN6KpR6KʚN6K@T<4BdBdN6KpR6KʚN6K@T g4>d>dN6KiJpR6KN6K p@ ppph___PPT2001D<4Xi? %* Chapter 18$Practical Applications of Immunology%%D/Vaccine History".Variolation: Inoculation of smallpox into skin (18th century) Vaccination: Inoculation of cowpox into skin Herd immunity results when most of a population is immune to a disease.*2  zOTPrincipal Vaccines Used in the United States to Prevent Bacterial Diseases in Humans UTcDtaP Diphtheria: Purified diphtheria toxoid Pertussis: Acellular fragments of B. pertussis Tetanus: Purified tetanus toxoid Meningococcal meningitis: Purified polysaccharide from N. meningitidis Haemophilus influenzae type b meningitis: Polysaccharides conjugated with protein Pneumococcal conjugate vaccine: S. pneumoniae antigens conjugated with protein~wI "7\ "   ,$;  "{PPPrincipal Vaccines Used in the United States to Prevent Viral Diseases in Humans QPBSmallpox: Live vaccinia virus Poliomyelitis: Inactivated virus Rabies: Inactivated virus Hepatitis A: Inactivated virus Influenza: Inactivated or attenuated virus Measles: Attenuated virus Mumps: Attenuated virus Rubella: Attenuated virus Chickenpox: Attenuated virus Hepatitis B: Antigenic fragments (recombinant vaccine) ,[Precipitation Reactions (Involve soluble antigens with antibodies )\Agglutination Reactions Involve particulate antigens and antibodies Antigens may be: On a cell (direct agglutination) Attached to latex spheres (indirect or passive agglutination)&#r ]Antibody Titer ?Is the concentration of antibodies against a particular antigen@@ @~S Hemagglutination involves agglutination of RBCs. Viral hemagglutination inhibition tests for antibodies by the antibodies' ability to prevent viruses from agglutinating RBCs.HaT MNeutralization reactions eliminate the harmful effect of a virus or exotoxin.C G3Complement Fixation UFluorescent-Antibody Techniques  V0Enzyme-Linked Immunosorbent Assay (Direct ELISA) 10,  W3Enzyme-Linked Immunosorbent Assay (Indirect ELISA) 43,  X  Y hDirect tests detect antigens (from patient sample) Indirect tests detect antibodies (in patient's serum)Z -Agglutination: Particulate antigens Hemagglutination: Agglutination of RBCs Precipitation: Soluble antigens Fluorescent-antibody technique: Antibodies linked to fluorescent dye Complement fixation: RBCs are indicator Neutralization: Inactivates toxin or virus ELISA: Peroxidase enzyme is the indicator   :     p;( ^J^J7 r  S :J` ]   x  c $8:JQY      08=J,$, = Figure 18.5   0  c #}A18-05_DirectAgglut_1.jpg 00030347 Macintosh HD ABA78158:[ YH  0޽h ? 33r *]  .( xy   ( frame.html(frame.html(frame.html(frame.html/ 0DTimes New RomanJ6KpR6KNJiBJ6KNJiDArialNew RomanJ6KpR6KNJiBJ6KNJi DGenevaew RomanJ6KpR6KNJiBJ6KNJi0DWingdingsRomanJ6KpR6KNJiBJ6KNJi@DTimesngsRomanJ6KpR6KNJiBJ6KNJiPDSymbolgsRomanJ6KpR6KNJiBJ6KNJi ` .  @n?" dd@  @@`` 0( p                R$*r3CVcqR$%}R ` o;pTR$ң J ?GR$X^Ɓ UwKYR$T$,y^<ܯw}S8R$=Tnz|_ZR$@rExUoX#) R$x.rѪ:<0NR$+ \N_)4ɻc $ fffffff@f8b} ʚ;2Nʚ;g4ZdZdN6KiJGJJ(J@p p@ <4!d!dN6KpR6KʚN6K@T<4ddddN6KpR6KʚN6K@T<4BdBdN6KpR6KʚN6K@T g4>d>dN6KiJpR6KN6K p@ ppph___PPT2001D<4Xi? % Chapter 18$Practical Applications of Immunology%%D/Vaccine History".Variolation: Inoculation of smallpox into skin (18th century) Vaccination: Inoculation of cowpox into skin Herd immunity results when most of a population is immune to a disease.*2  zOTPrincipal Vaccines Used in the United States to Prevent Bacterial Diseases in Humans UTcDtaP Diphtheria: Purified diphtheria toxoid Pertussis: Acellular fragments of B. pertussis Tetanus: Purified tetanus toxoid Meningococcal meningitis: Purified polysaccharide from N. meningitidis Haemophilus influenzae type b meningitis: Polysaccharides conjugated with protein Pneumococcal conjugate vaccine: S. pneumoniae antigens conjugated with protein~wI "7\ "   ,$;  "{PPPrincipal Vaccines Used in the United States to Prevent Viral Diseases in Humans QPBSmallpox: Live vaccinia virus Poliomyelitis: Inactivated virus Rabies: Inactivated virus Hepatitis A: Inactivated virus Influenza: Inactivated or attenuated virus Measles: Attenuated virus Mumps: Attenuated virus Rubella: Attenuated virus Chickenpox: Attenuated virus Hepatitis B: Antigenic fragments (recombinant vaccine) ,[Precipitation Reactions (Involve soluble antigens with antibodies )\Agglutination Reactions Involve particulate antigens and antibodies Antigens may be: On a cell (direct agglutination) Attached to latex spheres (indirect or passive agglutination)&#r ]Antibody Titer ?Is the concentration of antibodies against a particular antigen@@ @^Hemagglutination Hemagglutination involves agglutination of RBCs. Viral hemagglutination inhibition tests for antibodies by the antibodies' ability to prevent viruses from agglutinating RBCs. T MNeutralization reactions eliminate the harmful effect of a virus or exotoxin.C G3Complement Fixation UFluorescent-Antibody Techniques  V0Enzyme-Linked Immunosorbent Assay (Direct ELISA) 10,  W3Enzyme-Linked Immunosorbent Assay (Indirect ELISA) 43,  X  Y hDirect tests detect antigens (from patient sample) Indirect tests detect antibodies (in patient's serum)Z -Agglutination: Particulate antigens Hemagglutination: Agglutination of RBCs Precipitation: Soluble antigens Fluorescent-antibody technique: Antibodies linked to fluorescent dye Complement fixation: RBCs are indicator Neutralization: Inactivates toxin or virus ELISA: Peroxidase enzyme is the indicator   :     5(  r  S xd>dN6KiJpR6KN6K p@ ppph___PPT2001D<4Xi? % Chapter 18$Practical Applications of Immunology%%D/Vaccine History".Variolation: Inoculation of smallpox into skin (18th century) Vaccination: Inoculation of cowpox into skin Herd immunity results when most of a population is immune to a disease.*2  zOTPrincipal Vaccines Used in the United States to Prevent Bacterial Diseases in Humans UTcDtaP Diphtheria: Purified diphtheria toxoid Pertussis: Acellular fragments of B. pertussis Tetanus: Purified tetanus toxoid Meningococcal meningitis: Purified polysaccharide from N. meningitidis Haemophilus influenzae type b meningitis: Polysaccharides conjugated with protein Pneumococcal conjugate vaccine: S. pneumoniae antigens conjugated with protein~wI "7\ "   ,$;  "{PPPrincipal Vaccines Used in the United States to Prevent Viral Diseases in Humans QPBSmallpox: Live vaccinia virus Poliomyelitis: Inactivated virus Rabies: Inactivated virus Hepatitis A: Inactivated virus Influenza: Inactivated or attenuated virus Measles: Attenuated virus Mumps: Attenuated virus Rubella: Attenuated virus Chickenpox: Attenuated virus Hepatitis B: Antigenic fragments (recombinant vaccine) ,[Precipitation Reactions (Involve soluble antigens with antibodies )\Agglutination Reactions Involve particulate antigens and antibodies Antigens may be: On a cell (direct agglutination) Attached to latex spheres (indirect or passive agglutination)&#r ]Antibody Titer ?Is the concentration of antibodies against a particular antigen@@ @^Hemagglutination Hemagglutination involves agglutination of RBCs. Viral hemagglutination inhibition tests for antibodies by the antibodies' ability to prevent viruses from agglutinating RBCs. _Neutralization Reactions 3Eliminate the harmful effect of a virus or exotoxin44 4G3Complement Fixation UFluorescent-Antibody Techniques  V0Enzyme-Linked Immunosorbent Assay (Direct ELISA) 10,  W3Enzyme-Linked Immunosorbent Assay (Indirect ELISA) 43,  X  Y hDirect tests detect antigens (from patient sample) Indirect tests detect antibodies (in patient's serum)Z -Agglutination: Particulate antigens Hemagglutination: Agglutination of RBCs Precipitation: Soluble antigens Fluorescent-antibody technique: Antibodies linked to fluorescent dye Complement fixation: RBCs are indicator Neutralization: Inactivates toxin or virus ELISA: Peroxidase enzyme is the indicator   :     <( n` r  S BJ` ]   x  c $J,$, > Figure 18.8b   0  c D A18-08_Neutralization_1.jpg 00030347 Macintosh HD ABA78158:HH  0޽h ? 33rRr_ Rv- ( xy   ( frame.html(frame.html(frame.html(frame.html/ 0DTimes New RomanJ6KpR6KNJiBJ6KNJiDArialNew RomanJ6KpR6KNJiBJ6KNJi DGenevaew RomanJ6KpR6KNJiBJ6KNJi0DWingdingsRomanJ6KpR6KNJiBJ6KNJi@DTimesngsRomanJ6KpR6KNJiBJ6KNJiPDSymbolgsRomanJ6KpR6KNJiBJ6KNJi ` .  @n?" dd@  @@`` @80u               R$*r3CVcqR$%}R ` o;pTR$ң J ?GR$X^Ɓ UwKYR$T$,y^<ܯw}S8R$=Tnz|_ZR$@rExUoX#) R$x.rѪ:<0NR$+ \N_)4ɻc $ fffffff@f8b} ʚ;2Nʚ;g4ZdZdN6KiJGJJ(J@p p@ <4!d!dN6KpR6KʚN6K@T<4ddddN6KpR6KʚN6K@T<4BdBdN6KpR6KʚN6K@T g4>d>dN6KiJpR6KN6K p@ ppph___PPT2001D<4Xi? %y Chapter 18$Practical Applications of Immunology%%D/Vaccine History".Variolation: Inoculation of smallpox into skin (18th century) Vaccination: Inoculation of cowpox into skin Herd immunity results when most of a population is immune to a disease.*2  zOTPrincipal Vaccines Used in the United States to Prevent Bacterial Diseases in Humans UTcDtaP Diphtheria: Purified diphtheria toxoid Pertussis: Acellular fragments of B. pertussis Tetanus: Purified tetanus toxoid Meningococcal meningitis: Purified polysaccharide from N. meningitidis Haemophilus influenzae type b meningitis: Polysaccharides conjugated with protein Pneumococcal conjugate vaccine: S. pneumoniae antigens conjugated with protein~wI "7\ "   ,$;  "{PPPrincipal Vaccines Used in the United States to Prevent Viral Diseases in Humans QPBSmallpox: Live vaccinia virus Poliomyelitis: Inactivated virus Rabies: Inactivated virus Hepatitis A: Inactivated virus Influenza: Inactivated or attenuated virus Measles: Attenuated virus Mumps: Attenuated virus Rubella: Attenuated virus Chickenpox: Attenuated virus Hepatitis B: Antigenic fragments (recombinant vaccine) ,[Precipitation Reactions (Involve soluble antigens with antibodies )\Agglutination Reactions Involve particulate antigens and antibodies Antigens may be: On a cell (direct agglutination) Attached to latex spheres (indirect or passive agglutination)&#r ]Antibody Titer ?Is the concentration of antibodies against a particular antigen@@ @^Hemagglutination Hemagglutination involves agglutination of RBCs. 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Viral hemagglutination inhibition tests for antibodies by the antibodies' ability to prevent viruses from agglutinating RBCs. _Neutralization Reactions 3Eliminate the harmful effect of a virus or exotoxin44 4G3Complement Fixation `Complement Fixation U(Fluorescent Antibody Techniques (Direct) )($ a*Fluorescent Antibody Techniques (Indirect) +*$ V0Enzyme-Linked Immunosorbent Assay (Direct ELISA) 10,  W3Enzyme-Linked Immunosorbent Assay (Indirect ELISA) 43,  X  Y hDirect tests detect antigens (from patient sample) Indirect tests detect antibodies (in patient's serum)Z -Agglutination: Particulate antigens Hemagglutination: Agglutination of RBCs Precipitation: Soluble antigens Fluorescent-antibody technique: Antibodies linked to fluorescent dye Complement fixation: RBCs are indicator Neutralization: Inactivates toxin or virus ELISA: Peroxidase enzyme is the indicator   :     `1( }ff `x ` c $(JY     ` 0J,$, Y Figure 18.10a  * ` S PkA 18-10_FA-technique_1.jpg 00030347 Macintosh HD ABA78158: R ` s *K  H ` 0޽h ? 33  ?(  x  c $=JY      0AJ,$, a Figure 18.10b  0  c A 18-10_FA-technique_1.jpg 00030347 Macintosh HD ABA78158:k R  s *u H  0޽h ? 33rV !( xy   ( frame.html(frame.html(frame.html(frame.html/ 0DTimes New RomanJ6KpR6KNJiBJ6KNJiDArialNew RomanJ6KpR6KNJiBJ6KNJi DGenevaew RomanJ6KpR6KNJiBJ6KNJi0DWingdingsRomanJ6KpR6KNJiBJ6KNJi@DTimesngsRomanJ6KpR6KNJiBJ6KNJiPDSymbolgsRomanJ6KpR6KNJiBJ6KNJi ` .  @n?" dd@  @@`` XPH}               R$*r3CVcqR$%}R ` o;pTR$ң J ?GR$X^Ɓ UwKYR$T$,y^<ܯw}S8R$=Tnz|_ZR$@rExUoX#) R$x.rѪ:<0NR$+ \N_)4ɻc $ fffffff@8b} ʚ;2Nʚ;g4ZdZdN6KiJGJJ(J@p p@ <4!d!dN6KpR6KʚN6K@T<4ddddN6KpR6KʚN6K@T<4BdBdN6KpR6KʚN6K@T g4>d>dN6KiJpR6KN6K p@ ppph___PPT2001D<4Xi? % Chapter 18$Practical Applications of Immunology%%D/Vaccine History".Variolation: Inoculation of smallpox into skin (18th century) Vaccination: Inoculation of cowpox into skin Herd immunity results when most of a population is immune to a disease.*2  zOTPrincipal Vaccines Used in the United States to Prevent Bacterial Diseases in Humans UTcDtaP Diphtheria: Purified diphtheria toxoid Pertussis: Acellular fragments of B. pertussis Tetanus: Purified tetanus toxoid Meningococcal meningitis: Purified polysaccharide from N. meningitidis Haemophilus influenzae type b meningitis: Polysaccharides conjugated with protein Pneumococcal conjugate vaccine: S. pneumoniae antigens conjugated with protein~wI "7\ "   ,$;  "{PPPrincipal Vaccines Used in the United States to Prevent Viral Diseases in Humans QPBSmallpox: Live vaccinia virus Poliomyelitis: Inactivated virus Rabies: Inactivated virus Hepatitis A: Inactivated virus Influenza: Inactivated or attenuated virus Measles: Attenuated virus Mumps: Attenuated virus Rubella: Attenuated virus Chickenpox: Attenuated virus Hepatitis B: Antigenic fragments (recombinant vaccine) ,[Precipitation Reactions (Involve soluble antigens with antibodies )\Agglutination Reactions Involve particulate antigens and antibodies Antigens may be: On a cell (direct agglutination) Attached to latex spheres (indirect or passive agglutination)&#r ]Antibody Titer ?Is the concentration of antibodies against a particular antigen@@ @^Hemagglutination Hemagglutination involves agglutination of RBCs. 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